Using a panel of techniques, including a ribonucleoproteomic approach based on tagged protein affinity purification combined with next-generation sequencing, Chazal et al. show that the cytoplasmic sensor RIG-I plays a key role in cellular defense against Dengue and Zika viruses.
Chazal, M., Beauclair, G., Gracias, S., Najburg, V., Simon-Lorière, E., Tangy, F., … Jouvenet, N. (2018). RIG-I Recognizes the 5′ Region of Dengue and Zika Virus Genomes. Cell Reports, 24(2), 320–328. https://doi.org/10.1016/j.celrep.2018.06.047