The pathogen sensor RIG-I recognizes viral RNA and signals to induce an antiviral response. In this issue of Cell Host & Microbe, Weber et al. (2015), along with recent work by Sato et al. (2015), demonstrate that RIG-I directly inhibits viral replication independent of antiviral signaling.
Chan, Y. K., & Gack, M. U. (2015, March 11). RIG-I works double duty. Cell Host and Microbe. Cell Press. https://doi.org/10.1016/j.chom.2015.02.014