Many pre-mRNA splicing factors are phosphorylated in vivo, but the role of this modification has been unclear. Recent observations suggest that phosphorylation modulates protein-protein interactions within the spliceosome, thereby contributing to dynamic structural reorganization of the spliceosome during splicing.
Misteli, T. (1999, March 25). RNA splicing: What has phosphorylation got to do with it? Current Biology. Current Biology Ltd. https://doi.org/10.1016/S0960-9822(99)80128-6