Ewing's sarcomas are aggressive musculoskeletal tumors occurring most frequently in the long and flat bones as a solitary lesion mostly during the teen-age years of life. With current treatments, significant number of patients relapse and survival is poor for those with metastatic disease. As part of novel target discovery in Ewing's sarcoma, we applied RNAi mediated phenotypic profiling to identify kinase targets involved in growth and survival of Ewing's sarcoma cells.
Arora, S., Gonzales, I. M., Hagelstrom, R. T., Beaudry, C., Choudhary, A., Sima, C., … Azorsa, D. O. (2010). RNAi phenotype profiling of kinases identifies potential therapeutic targets in Ewing’s sarcoma. Molecular Cancer, 9. https://doi.org/10.1186/1476-4598-9-218