In this issue of Molecular Cell, Bandyra et al. (2012) describe how a bacterial sRNA can lead to degradation of an mRNA by pairing within the coding region of the mRNA; the 5' monophosphate end of the sRNA activates RNase E, leading to rapid cleavage of the paired mRNA. © 2012 Elsevier Inc.
De Lay, N., & Gottesman, S. (2012, September 28). RNase E Finds Some sRNAs Stimulating. Molecular Cell. https://doi.org/10.1016/j.molcel.2012.09.007