The role of aspirin desensitization in patients with aspirin-exacerbated respiratory disease (AERD)

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Abstract

Introduction: Aspirin-exacerbated respiratory disease (AERD) consists of a classic tetrad: moderate/severe asthma, chronic rhinosinusitis, nasal polyps, and intolerance to aspirin or other nonsteroidal anti-inflammatory drugs. Clinical control with drugs, surgery, and desensitization are treatment options. Objective: To evaluate the efficacy and tolerability of aspirin desensitization in patients with AERD. Methods: Periodic symptom assessment and endoscopy in patients with AERD undergoing surgery who were desensitized. Results: Seventeen patients were desensitized. Eight patients completed the desensitization and were followed for a minimum of a one-year period (mean 3.1 years). These patients showed improvement in all symptoms. Moreover, surgical reassessment was not indicated in any of these patients and there was a decrease in costs with medication and procedures. Eight patients did not complete desensitization, mainly due to procedure intolerance and uncontrolled asthma, whereas another patient was lost to follow-up. Conclusion: Aspirin desensitization, when tolerated, was effective in patients with AERD and with poor clinical/surgical response.

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Spies, J. W., Valera, F. C. P., Cordeiro, D. L., de Mendonça, T. N., Leite, M. G. J., Tamashiro, E., … Anselmo-Lima, W. T. (2016). The role of aspirin desensitization in patients with aspirin-exacerbated respiratory disease (AERD). Brazilian Journal of Otorhinolaryngology, 82(3), 263–268. https://doi.org/10.1016/j.bjorl.2015.04.010

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