The role of bestrophin in airway epithelial ion transport

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Abstract

The purpose of this study was to identify Cl- channels in the basolateral membrane of airway epithelial cells at the molecular level. We have focused on a new family of Cl- channels, bestrophins, which have previously been identified in retinal pigment epithelium. RT-PCR, Western blot and confocal microscopy studies revealed the presence of bestrophin in airway epithelial cells. Decreasing bestrophin expression using siRNA resulted in diminished 36Cl- flux. These studies also showed that bestrophin regulation is similar to that of native basolateral Cl- channels. The data indicate that the presence of a functional bestrophin may contribute to the basolateral cell conductance in airway epithelial cells. © 2004 Published by Elsevier B.V. on behalf of the Federation of European Biochemical Societies.

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Duta, V., Szkotak, A. J., Nahirney, D., & Duszyk, M. (2004). The role of bestrophin in airway epithelial ion transport. FEBS Letters, 577(3), 551–554. https://doi.org/10.1016/j.febslet.2004.10.068

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