The Role of Galectins as Modulators of Metabolism and Inflammation

  • Brinchmann M
  • Patel D
  • Iversen M
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Abstract

Galectins are β -galcotosid-binding lectins. The function of galectins varies with their tissue-specific and subcellular location, and their binding to carbohydrates makes them key players in several intra- and extracellular processes where they bind to glycosylated proteins and lipids. In humans, there are 12 identified galectins, some with tissue-specific distribution. Galectins are found inside cells and in the nucleus, cytosol, and organelles, as well as extracellularly. Galectin-1, -2, -3, -4, -7, -8, -9, and -12 can all induce T-cell apoptosis and modulate inflammation. In the context of metabolic control and loss of the same in, for example, diabetes, galectin-1, -2, -3, -9, and -12 are especially interesting. This review presents information on galectins relevant to the control of inflammation and metabolism and the potential to target galectins for therapeutic purposes.

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Brinchmann, M. F., Patel, D. M., & Iversen, M. H. (2018). The Role of Galectins as Modulators of Metabolism and Inflammation. Mediators of Inflammation, 2018, 1–11. https://doi.org/10.1155/2018/9186940

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