Role of Hematopoietic Stem Cell Transplantation in Multiple Myeloma

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Abstract

High-dose therapy followed by autologous stem cell transplantation (ASCT) has been the standard frontline consolidative therapy for patients with newly diagnosed multiple myeloma (MM) for > 2 decades. This approach has resulted in higher complete response (CR) rates and increased event-free survival and overall survival (OS) compared with conventional chemotherapy. The emergence of novel agent-based therapy combined with ASCT has revolutionized MM therapy by improving the CR rates and OS, raising questions concerning the role of hematopoietic stem cell transplantation in this setting.

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Garcia, I. N. (2015, February 1). Role of Hematopoietic Stem Cell Transplantation in Multiple Myeloma. Clinical Lymphoma, Myeloma and Leukemia. Elsevier Inc. https://doi.org/10.1016/j.clml.2014.07.007

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