Epidemiological evidence suggests that hypertension may accelerate the onset and progression of Alzheimer's disease (AD). In this study, we explored the role of hypertension in the neurodegenerative changes associated with A β and tau aggregation. We induced hypertension in APPswe Tg2576 and P301L-tauTg mouse models. In Tg2576 mice, experimental hypertension was associated with a significant increase of the accumulation of Amyloid- β (A β ) peptides in brain tissue and a significant reduction of A β peptides in serum (P<.05) . These results indicate that hypertension may promote AD-type A β neuropathology in Tg2576. In P301L-tauTg mice we found that the presence of hypertension was significantly associated with aggravated motor function assessed by hindlimb extension test (P=.01) . These results suggest that hypertension may play a role in accelerating the progression of motor dysfunction associated with tau-related alterations. Our studies suggest that the management of blood pressure (BP) may alleviate AD-type A β neuropathology and neurological disorders associated with abnormal tau metabolism.
Díaz-Ruiz, C., Wang, J., Ksiezak-Reding, H., Ho, L., Qian, X., Humala, N., … Pasinetti, G. M. (2009). Role of Hypertension in Aggravating A β Neuropathology of AD Type and Tau-Mediated Motor Impairment . Cardiovascular Psychiatry and Neurology, 2009, 1–9. https://doi.org/10.1155/2009/107286