The role of nucleotides and purinergic signaling in apoptotic cell clearance - implications for chronic inflammatory diseases

17Citations
Citations of this article
33Readers
Mendeley users who have this article in their library.

Abstract

Billions of cells undergo apoptosis every day in healthy individuals. A prompt removal of dying cells prevents the release of pro-inflammatory intracellular content and progress to secondary necrosis. Thus, inappropriate clearance of apoptotic cells provokes autoimmunity and has been associated with many chronic inflammatory diseases. Recent studies have suggested that extracellular adenosine 5'-triphosphate and related nucleotides play an important role in the apoptotic clearance process. Here, we review the current understanding of nucleotides and purinergic receptors in apoptotic cell clearance and the potential therapeutic targets of purinergic receptor subtypes in inflammatory conditions.

Cite

CITATION STYLE

APA

Chen, J., Zhao, Y., & Liu, Y. (2014). The role of nucleotides and purinergic signaling in apoptotic cell clearance - implications for chronic inflammatory diseases. Frontiers in Immunology, 5(DEC). https://doi.org/10.3389/fimmu.2014.00656

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free