The role of protein kinase C in the induction of VCAM-1 expression on human umbilical vein endothelial cells

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Abstract

The role of protein kinase C (PKC) in interleukin-1β- (II- 1β)-, tumor necrosis factor-α- (TNF-α)-, and lipopolysaccharide-(LPS)-induced vascular cell adhesion molecule-1 (VCAM-1) expression on human umbilical vein endothelial cells (HUVEC) was studied. PKC inhibition or downregulation diminished VCAM-1 mRNA accumulation and protein expression. Interleukin-1β, TNF-α, and LPS induce nuclear factor (NF)-kB-like binding activity, which precedes VCAM-1 transcription. PKC inhibition did not prevent NF-xB-like binding activity, indicating that this is PKC-independent, and NF-kB-like binding activity is insufficient for transcription of VCAM-1. © 1993.

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Deisher, T. A., Haddix, T. L., Montgomery, K. F., Pohlman, T. H., Kaushansky, K., & Harlan, J. M. (1993). The role of protein kinase C in the induction of VCAM-1 expression on human umbilical vein endothelial cells. FEBS Letters, 331(3), 285–290. https://doi.org/10.1016/0014-5793(93)80354-W

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