Roots of erigeron annuus attenuate acute inflammation as mediated with the inhibition of NF-κB-associated nitric oxide and prostaglandin Eproduction

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Abstract

Erigeron annuus is a naturalized plant belonging to Compositae (asteraceae) family, which is called the annual fleabane, and commonly found at meadows and roadside. This study investigated the anti-inflammatory effects of the extract of E. annuus roots (EER), as assessed by the paw edema formation and histological analysis in rat, and the productions of nitric oxide (NO), prostaglandin E 2 (PGE 2 ), and pro-inflammatory cytokines in Raw264.7 murine macrophages. Carrageenan treatment promoted infiltration of inflammatory cells and caused swelling in the hind paw. Oral administrations of EER (0.3 g/kg and 1 g/kg) attenuated acute inflammation similar to the result using dexamethasone (1 mg/kg). Treatment of macrophages with lipopolysaccharide (LPS) simulated inflammatory condition: LPS significantly increased the productions of NO, PGE 2 , and proinflammatory cytokines. EER suppressed activation of macrophages, preventing the induction of iNOS and COX-2 protein expressions. LPS treatment induced phosphorylation of I- κ B α and increased the level of nuclear NF- κ B protein, both of which were suppressed by concomitant treatment of EER. In conclusion, EER ameliorated acute inflammation in rats, and the induction of NO, PGE 2 , and proinflammatory cytokines in Raw264.7 cells. EER’s effects may be associated with its inhibition of NF- κ B activation, suggesting its effect on inflammatory diseases.

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Jo, M. J., Lee, J. R., Cho, I. J., Kim, Y. W., & Kim, S. C. (2013). Roots of erigeron annuus attenuate acute inflammation as mediated with the inhibition of NF-κB-associated nitric oxide and prostaglandin Eproduction. Evidence-Based Complementary and Alternative Medicine, 2013. https://doi.org/10.1155/2013/297427

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