RORα, a potential tumor suppressor and therapeutic target of breast cancer

31Citations
Citations of this article
22Readers
Mendeley users who have this article in their library.

Abstract

The function of the nuclear receptor (NR) in breast cancer progression has been investigated for decades. The majority of the nuclear receptors have well characterized natural ligands, but a few of them are orphan receptors for which no ligand has been identified. RORα, one member of the retinoid orphan nuclear receptor (ROR) subfamily of orphan receptors, regulates various cellular and pathological activities. RORα is commonly down-regulated and/or hypoactivated in breast cancer compared to normal mammary tissue. Expression of RORα suppresses malignant phenotypes in breast cancer cells, in vitro and in vivo. Activity of RORα can be categorized into the canonical and non-canonical nuclear receptor pathways, which in turn regulate various breast cancer cellular function, including cell proliferation, apoptosis and invasion. This information suggests that RORα is a potent tumor suppressor and a potential therapeutic target for breast cancer. © 2012 by the authors; licensee MDPI, Basel, Switzerland.

Cite

CITATION STYLE

APA

Du, J., & Xu, R. (2012). RORα, a potential tumor suppressor and therapeutic target of breast cancer. International Journal of Molecular Sciences. MDPI AG. https://doi.org/10.3390/ijms131215755

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free