Replication protein A, the heterotrimeric single-stranded DNA binding factor in eukaryotic cells, interacts with DNA in both an unstable and stable mode. Biochemical, mutational, and crystallographic analyses have provided insights into the switch between these two states.
Krejci, L., & Sung, P. (2002). RPA not that different from SSB. Structure. Cell Press. https://doi.org/10.1016/S0969-2126(02)00765-7