Safety assessment of coleopteran active IPD072Aa protein from Psuedomonas chlororaphis

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The ipd072Aa gene from Pseudomonas chlororaphis encodes the IPD072Aa protein which confers protection against certain coleopteran pests when expressed in genetically modified (GM)plants. A weight of evidence approach was used to assess the safety of the IPD072Aa protein. This approach considered the history of safe use of the source organism and bioinformatic comparison of the protein sequence with known allergenic and toxic proteins. The IPD072Aa protein was assessed for resistance to degradation in the presence of simulated gastric fluid containing pepsin as well as heat stability. There was no hazard identified with the IPD072Aa protein. Furthermore, an acute oral toxicity study found no evidence of adverse effects. Collectively, these studies support the human health safety assessment of the IPD072Aa protein.




Carlson, A. B., Mathesius, C. A., Ballou, S., Boeckman, C. J., Gunderson, T. A., Mirsky, H. P., … Delaney, B. (2019). Safety assessment of coleopteran active IPD072Aa protein from Psuedomonas chlororaphis. Food and Chemical Toxicology, 129, 376–381.

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