Safety assessment of coleopteran active IPD072Aa protein from Psuedomonas chlororaphis

0Citations
Citations of this article
5Readers
Mendeley users who have this article in their library.

Abstract

The ipd072Aa gene from Pseudomonas chlororaphis encodes the IPD072Aa protein which confers protection against certain coleopteran pests when expressed in genetically modified (GM)plants. A weight of evidence approach was used to assess the safety of the IPD072Aa protein. This approach considered the history of safe use of the source organism and bioinformatic comparison of the protein sequence with known allergenic and toxic proteins. The IPD072Aa protein was assessed for resistance to degradation in the presence of simulated gastric fluid containing pepsin as well as heat stability. There was no hazard identified with the IPD072Aa protein. Furthermore, an acute oral toxicity study found no evidence of adverse effects. Collectively, these studies support the human health safety assessment of the IPD072Aa protein.

Cite

CITATION STYLE

APA

Carlson, A. B., Mathesius, C. A., Ballou, S., Boeckman, C. J., Gunderson, T. A., Mirsky, H. P., … Delaney, B. (2019). Safety assessment of coleopteran active IPD072Aa protein from Psuedomonas chlororaphis. Food and Chemical Toxicology, 129, 376–381. https://doi.org/10.1016/j.fct.2019.04.055

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free