SAMMA, a mandelic acid condensation polymer, inhibits dendritic cell-mediated HIV transmission

13Citations
Citations of this article
11Readers
Mendeley users who have this article in their library.

Abstract

SAMMA, a mandelic acid condensation polymer, exhibits a broad antimicrobial activity against several sexually transmitted pathogens including human immunodeficiency virus (HIV). Here we demonstrated that SAMMA suppressed HIV transmission by dendritic cells (DCs), one of the first target cells for primary infection. The greatest inhibitory effect was achieved when SAMMA was present during the co-culture with target cells. The inhibitory effect of SAMMA on DC-mediated HIV transmission was not due to cytotoxicity. Analysis of the level of DC-associated HIV p24 antigen revealed that SAMMA prevented HIV internalization by DCs when the virus was pre-incubated with the compound. In contrast, pre-incubation of DCs with SAMMA followed by wash-off did not affect the amount of cell-associated HIV p24 antigen. In addition, SAMMA blocked HIV glycoprotein-mediated cell-cell fusion. This study suggests that SAMMA prevents HIV infection through multiple mechanisms. © 2007 Federation of European Biochemical Societies.

Cite

CITATION STYLE

APA

Chang, T. L., Teleshova, N., Rapista, A., Paluch, M., Anderson, R. A., Waller, D. P., … Klotman, M. E. (2007). SAMMA, a mandelic acid condensation polymer, inhibits dendritic cell-mediated HIV transmission. FEBS Letters, 581(24), 4596–4602. https://doi.org/10.1016/j.febslet.2007.08.048

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free