Schiff's bases of quinazolinone derivatives: Synthesis and SAR studies of a novel series of potential anti-inflammatory and antioxidants

45Citations
Citations of this article
54Readers
Mendeley users who have this article in their library.

Abstract

A series of quinazolinone derived Schiff base derivatives 7-28 were synthesized and characterized as novel antioxidants and anti-inflammatory agents. The in vitro antioxidant activities of these compounds were evaluated and compared with commercial antioxidants ascorbic acid (AA), gallic acid (GA), butylatedhydroxytoluene (BHT), butylatedhydroxyanisole (BHA) employing 1,1-diphenyl-2-picryl-hydrazyl (DPPH) assay, 2,2-azinobis-(3-ethylbenzothiazoline-6-sufonic acid) (ABTS) assay and N,N-dimethyl-p-phenylenediamine dihydrochloride (DMPD) assay. The results revealed that IC50 of 17, 18, 23, 24, 25, 27 and 28 were lower than the IC50 of standards in all the three performed antioxidant assays indicating good activities of these compounds. In addition, in vitro anti-inflammatory activity of the synthesized compounds were evaluated and the results demonstrate that the compounds 9-12 exhibited excellent anti-inflammatory activity. Preliminary structure-activity relationship revealed that the compounds 17, 18, 23, 24, 25, 27 and 28 with electron donating moiety (OH, OCH3) were found to be excellent antioxidants and compounds 9, 10, 11 and 12 with electron withdrawing moiety (Cl, NO2) were found to be excellent anti-inflammatory agents.

Cite

CITATION STYLE

APA

Rakesh, K. P., Manukumar, H. M., & Gowda, D. C. (2015). Schiff’s bases of quinazolinone derivatives: Synthesis and SAR studies of a novel series of potential anti-inflammatory and antioxidants. Bioorganic and Medicinal Chemistry Letters, 25(5), 1072–1077. https://doi.org/10.1016/j.bmcl.2015.01.010

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free