Searching for SNPs with cloud computing

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As DNA sequencing outpaces improvements in computer speed, there is a critical need to accelerate tasks like alignment and SNP calling. Crossbow is a cloud-computing software tool that combines the aligner Bowtie and the SNP caller SOAPsnp. Executing in parallel using Hadoop, Crossbow analyzes data comprising 38-fold coverage of the human genome in three hours using a 320-CPU cluster rented from a cloud computing service for about $85. Crossbow is available from© 2009 Langmead et al; licensee BioMed Central Ltd.




Langmead, B., Schatz, M. C., Lin, J., Pop, M., & Salzberg, S. L. (2009). Searching for SNPs with cloud computing. Genome Biology, 10(11).

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