Seed-in-soil: Pancreatic cancer influenced by tumor microenvironment

13Citations
Citations of this article
39Readers
Mendeley users who have this article in their library.

Abstract

Pancreatic ductal adenocarcinoma is a fatal malignancy with a five-year survival rate lower than 7%, and most patients dying within six months of diagnosis. The factors that contribute to the aggressiveness of the disease include, but are not limited to: late diagnosis, prompt metastasis to adjacent vital organs, poor response, and resistance to anticancer treatments. This malignancy is uniquely associated with desmoplastic stroma that accounts for 80% of tumor mass. Understanding the biology of stroma can aid the discovery of innovative strategies for eradicating this lethal cancer in the future. This review highlights the critical components in the stroma and how they interact with the cancer cells to convey the devastating tumor progression.

Cite

CITATION STYLE

APA

Lin, H. J., & Lin, J. (2017, July 21). Seed-in-soil: Pancreatic cancer influenced by tumor microenvironment. Cancers. MDPI AG. https://doi.org/10.3390/cancers9070093

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free