Semi-quantitative vs. volumetric determination of endolymphatic space in Menière's disease using endolymphatic hydrops 3T-HR-MRI after intravenous gadolinium injection

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Abstract

Magnetic resonance imaging enhances the clinical diagnosis of Menière's disease. This is accomplished by in vivo detection of endolymphatic hydrops, which are graded using different semi-quantitative grading systems. We evaluated an established, semi-quantitative endolymphatic hydrops score and with a quantitative method for volumetric assessment of the endolymphatic size. 11 patients with Menière's disease and 2 healthy subjects underwent high resolution endolymphatic hydrops 3 Tesla MRI with highly T2 weighted FLAIR and T2DRIVE sequences. The degree of endolymphatic hydrops was rated semi-quantitatively and compared to the results of 3D-volumetry. Moreover, the grade of endolymphatic hydrops was correlated with pure tone audiometry. Semi-quantitative grading and volumetric evaluation of the endolymphatic hydrops are in accordance (r = 0.92) and the grade of endolymphatic hydrops correlates with pure tone audiometry. Patients with a sickness duration of ≥ 30 months showed a significant higher total labyrinth fluid volume (p = 0.03). Fast, semi-quantitative evaluation of endolymphatic hydrops is highly reliable compared to quantitative/volumetric assessment. Endolymphatic space is significantly higher in patients with longer sickness duration.

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Homann, G., Vieth, V., Weiss, D., Nikolaou, K., Heindel, W., Notohamiprodjo, M., & Böckenfeld, Y. (2015). Semi-quantitative vs. volumetric determination of endolymphatic space in Menière’s disease using endolymphatic hydrops 3T-HR-MRI after intravenous gadolinium injection. PLoS ONE, 10(3). https://doi.org/10.1371/journal.pone.0120357

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