A sensitive dnazyme-based chiral sensor for lead detection

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A DNAzyme-based sensor for the determination and quantification of lead ions (Pb2+) has been established, which combines the recognition and catalysis of DNAzyme with the optical properties of nanomaterials. Circular dichroism (CD) signals were obtained by a DNAzyme-based assembly of asymmetric silver nanoparticle (AgNPs) dimers. A good linear relationship between CD signals and Pb2+ concentration was obtained ranging from 0.05 ng{bullet operator}mL-1 to 10 ng{bullet operator}mL-1 with a limit of detection (LOD) of 0.02 ng{bullet operator}mL-1. The specificity of this sensor in lead ion detection was excellent, and a satisfactory recovery was obtained in the analysis of tap water samples. The proposed technique possesses both high sensitivity and good specificity, giving it great potential for the analysis of Pb2+ in water. © 2013 by the authors.




Kuang, H., Yin, H., Xing, C., & Xu, C. (2013). A sensitive dnazyme-based chiral sensor for lead detection. Materials, 6(11), 5038–5046. https://doi.org/10.3390/ma6115038

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