T cell receptor interactions with peptide/major histocompatibility complex (pMHC) ligands control the selection of T cells in the thymus as well as their homeostasis in peripheral lymphoid organs. Here we show that pMHC contact modulates the expression of CD5 by naive CD4 T cells in a process that requires the continued expression of p56lck. Reduced CD5 levels in T cells deprived of pMHC contact are predictive of elevated Ca2+ responses to subsequent TCR engagement by anti-CD3 or nominal antigen. Adaptation to peripheral pMHC contact may be important for regulating naive CD4 T cell responsiveness.
CITATION STYLE
Smith, K., Seddon, B., Purbhoo, M. A., Zamoyska, R., Fisher, A. G., & Merkenschlager, M. (2001). Sensory adaptation in naive peripheral CD4 T cells. Journal of Experimental Medicine, 194(9), 1253–1261. https://doi.org/10.1084/jem.194.9.1253
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