Sensory experience modifies feature map relationships in visual cortex

  • Cloherty S
  • Hughes N
  • Hietanen M
  • et al.
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Abstract

The extent to which brain structure is influenced by sensory input during development is a critical but controversial question. A paradigmatic system for studying this is the mammalian visual cortex. Maps of orientation preference (OP) and ocular dominance (OD) in the primary visual cortex of ferrets, cats and monkeys can be individually changed by altered visual input. However, the spatial relationship between OP and OD maps has appeared immutable. Using a computational model we predicted that biasing the visual input to orthogonal orientation in the two eyes should cause a shift of OP pinwheels towards the border of OD columns. We then confirmed this prediction by rearing cats wearing orthogonally oriented cylindrical lenses over each eye. Thus, the spatial relationship between OP and OD maps can be modified by visual experience, revealing a previously unknown degree of brain plasticity in response to sensory input.The structure of the brain results from a combination of nature (genes) and nurture (environment). The brain’s ability to adapt to changes in the environment is known as plasticity, and the young brain is especially plastic. An animal’s sensory experiences in early life help to determine how its brain will process sensory input as an adult. One of the best sensory systems in which to study this process is the visual system.Within the visual system, some brain cells respond only to input from the left eye and others only to input from the right eye. Cells that respond to input from the same eye are arranged to form columns. Within each column, some cells respond only to lines with a particular orientation. Cells with different preferred orientations are grouped together in patterns that resemble pinwheels. The relative positions of the pinwheels and eye-specific columns within the brain tissue belonging to the visual system have so far been robust to changes in visual experience during development, suggesting that they are determined by an animal’s genes.However, Cloherty, Hughes et al. have now tested the unexpected predictions of a computer model. The model suggested that rearing animals so that they saw mostly vertical lines through one eye, and mostly horizontal lines through the other, would cause a form of plasticity that had never been observed before. Specifically, it would change the relative positions of the pinwheels and eye-specific columns within the visual parts of the brain. This prediction turned out to be correct. Young cats that wore special lenses – which slightly distorted what they saw but did not obviously affect their behavior – showed the predicted changes in brain structure.The results confirm that this aspect of brain structure is partly determined by nurture, as opposed to being entirely specified by nature. A key future challenge is to identify the chemical signaling that enables sensory input to have these effects on brain structure. It might then be possible to use drugs to restore normal brain activity in cases where abnormal sensory input has altered the brain, for example in the condition known as amblyopia (or “lazy eye”).

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APA

Cloherty, S. L., Hughes, N. J., Hietanen, M. A., Bhagavatula, P. S., Goodhill, G. J., & Ibbotson, M. R. (2016). Sensory experience modifies feature map relationships in visual cortex. ELife, 5. https://doi.org/10.7554/elife.13911

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