Separacenes A-D (1-4), novel polyene polyols, were isolated from Streptomyces sp. collected from the southern area of Jeju Island, Korea. The chemical structures of 1-4 were established by NMR, mass, UV, and IR spectroscopy as well as the modified Mosher's method. Separacenes A-B (1-2), which share an identical planar structure but possess different relative configurations, bear tetraene units flanked by two diol moieties, whereas the stereoisomeric separacenes C-D (3-4) possess a triene moiety between two diol substructures. Separacenes A-D each contain a terminal olefinic methylene. Separacene A displayed inhibitory activity against Candida albicans isocitrate lyase and weak cytotoxicity against both the colon carcinoma cell line HCT-116 and the lung cancer cell line A549.
Bae, M., Kim, H., Shin, Y., Kim, B. Y., Lee, S. K., Oh, K. B., … Oh, D. C. (2013). Separacenes A-D, novel polyene polyols from the marine actinomycete, streptomyces sp. Marine Drugs, 11(8), 2882–2893. https://doi.org/10.3390/md11082882