A sequence motif enriched in regions bound by the Drosophila dosage compensation complex

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Abstract

Background: In Drosophila melanogaster, dosage compensation is mediated by the action of the dosage compensation complex (DCC). How the DCC recognizes the fly X chromosome is still poorly understood. Characteristic sequence signatures at all DCC binding sites have not hitherto been found.Results: In this study, we compare the known binding sites of the DCC with oligonucleotide profiles that measure the specificity of the sequences of the D. melanogaster X chromosome. We show that the X chromosome regions bound by the DCC are enriched for a particular type of short, repetitive sequences. Their distribution suggests that these sequences contribute to chromosome recognition, the generation of DCC binding sites and/or the local spreading of the complex. Comparative data indicate that the same sequences may be involved in dosage compensation in other Drosophila species.Conclusions: These results offer an explanation for the wild-type binding of the DCC along the Drosophila X chromosome, contribute to delineate the forces leading to the establishment of dosage compensation and suggest new experimental approaches to understand the precise biochemical features of the dosage compensation system. © 2010 Gallach et al; licensee BioMed Central Ltd.

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Gallach, M., Arnau, V., Aldecoa, R., & Marín, I. (2010). A sequence motif enriched in regions bound by the Drosophila dosage compensation complex. BMC Genomics, 11(1). https://doi.org/10.1186/1471-2164-11-169

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