Biologically active, therapeutically useful, DNA binding natural products continue to reveal new paradigms for sequence-selective recognition, to enlist beautiful mechanisms of in situ activation for DNA modification, to define new therapeutic targets, to exploit new mechanisms to achieve cellular selectivity, and to provide a rich source of new drugs. These attributes arise in compact structures of complex integrated function.
Tse, W. C., & Boger, D. L. (2004, December). Sequence-selective DNA recognition: Natural products and nature’s lessons. Chemistry and Biology. https://doi.org/10.1016/j.chembiol.2003.08.012