Sequencing of agents for metastatic renal cell carcinoma: Can we customize therapy?

41Citations
Citations of this article
42Readers
Mendeley users who have this article in their library.

Abstract

Context: The expanding armamentarium of agents for the therapy of advanced clear cell renal cell carcinoma (RCC) warrants further investigation of optimal patient selection. Objective: To analyze the second and subsequent line of targeted therapies for advanced RCC while integrating clinical and molecular markers and imaging. Evidence acquisition: Data were acquired from research published in peer-reviewed literature or presented at major conferences. Evidence synthesis: Following first-line vascular endothelial growth factor (VEGF) inhibitors, second-line therapy with everolimus, a mammalian target of rapamycin inhibitor, and axitinib, a VEGF receptor tyrosine kinase inhibitor, have demonstrated benefits in progression-free survival (PFS). Sorafenib, pazopanib, and axitinib have demonstrated extension of PFS following cytokines. Optimal patient selection based on biomarkers is undergoing investigation. Clinical trials evaluating novel agents and combinations should be preferred. Conclusions: Currently, the sequence of therapy is based on patient and physician decision, which may be influenced by comorbidities and toxicity profiles. © 2011 European Association of Urology. Published by Elsevier B.V. All rights reserved.

Cite

CITATION STYLE

APA

Sonpavde, G., Choueiri, T. K., Escudier, B., Ficarra, V., Hutson, T. E., Mulders, P. F., … Stief, C. G. (2012, February). Sequencing of agents for metastatic renal cell carcinoma: Can we customize therapy? European Urology. https://doi.org/10.1016/j.eururo.2011.10.032

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free