Aim of the work: To investigate the possible role of serum homocysteine in the eye involvement in Egyptian patients with Behçet's disease (BD). Patients and methods: A case-control study was made on 27 patients with BD (17 males and 10 females with a mean age of 32.11 ± 7.16. years) and 19 healthy control subjects. All patients fulfilled the criteria of the International Study Group for BD. The patients were categorized as BD with eye involvement (n= 12), or BD without eye involvement (n= 15). Serum homocysteine and C-reactive protein levels were studied in all patients and controls. Results: The mean serum homocysteine concentrations were significantly higher in BD patients than in healthy controls (15.56 ± 3.52 and 7.32 ± 1.38. μmol/L, respectively; P < 0.001). Also, the mean serum homocysteine concentrations were significantly higher in BD patients with eye involvement compared to those without eye involvement (18.50 ± 3 and 13.2 ± 1.61. μmol/L, respectively; P < 0.001). CRP, as a marker of disease activity was significantly higher in BD patients than in controls (14.33 ± 8.28 and 3.21 ± 1.72. mg/L, respectively; P < 0.001), however, no significant difference (P= 0.213) in CRP levels was found between BD patients with or without eye involvement. Conclusion: Homocysteine may play a role in BD patients with ocular involvement. Assessment of homocysteine may be important in the investigation and management of patients with BD, especially with ocular disease. © 2013.
Allam, A., Ammar, H., & Radwan, A. (2014). Serum homocysteine level and eye involvement in Egyptian patients with Behçet’s disease. Egyptian Rheumatologist, 36(1), 29–34. https://doi.org/10.1016/j.ejr.2013.09.002