Soluble circulating proteins play an important role in the regulation of mating behavior in Drosophila melanogaster. However, how these factors signal through the blood-brain barrier (bbb) to interact with the sex-specific brain circuits that control courtship is unknown. Here we show that male identity of the blood-brain barrier is necessary and that male-specific factors in the bbb are physiologically required for normal male courtship behavior. Feminization of the bbb of adult males significantly reduces male courtship. We show that the bbb-specific G-protein coupled receptor moody and bbb-specific Go signaling in adult males are necessary for normal courtship. These data identify sex-specific factors and signaling processes in the bbb as important regulators of male mating behavior. © 2013 Hoxha et al.
Hoxha, V., Lama, C., Chang, P. L., Saurabh, S., Patel, N., Olate, N., & Dauwalder, B. (2013). Sex-Specific Signaling in the Blood-Brain Barrier Is Required for Male Courtship in Drosophila. PLoS Genetics, 9(1). https://doi.org/10.1371/journal.pgen.1003217