Short and Long Term Measures of Anxiety Exhibit Opposite Results

21Citations
Citations of this article
38Readers
Mendeley users who have this article in their library.

Abstract

Animal models of human diseases of the central nervous system, generalized anxiety disorder included, are essential for the study of the brain-behavior interface and obligatory for drug development; yet, these models fail to yield new insights and efficacious drugs. By increasing testing duration hundredfold and arena size tenfold, and comparing the behavior of the common animal model to that of wild mice, we raise concerns that chronic anxiety might have been measured at the wrong time, for the wrong duration, and in the wrong animal. Furthermore, the mice start the experimental session with a short period of transient adaptation to the novel environment (habituation period) and a long period reflecting the respective trait of the mice. Using common measures of anxiety reveals that mice exhibit opposite results during these periods suggesting that chronic anxiety should be measured during the post-habituation period. We recommend tools for measuring the transient period, and provide suggestions for characterizing the post habituation period. © 2012 Fonio et al.

Cite

CITATION STYLE

APA

Fonio, E., Benjamini, Y., & Golani, I. (2012). Short and Long Term Measures of Anxiety Exhibit Opposite Results. PLoS ONE, 7(10). https://doi.org/10.1371/journal.pone.0048414

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free