Short-term esmolol improves coronary artery remodeling in spontaneously hypertensive rats through increased nitric oxide bioavailability and superoxide dismutase activity

8Citations
Citations of this article
6Readers
Mendeley users who have this article in their library.

Abstract

The aim of this study was to assess the effects of short-term esmolol therapy on coronary artery structure and function and plasma oxidative stress in spontaneously hypertensive rats (SHR). For this purpose, 14-month-old male SHR were treated for 48 hours with esmolol (SHR-E, 300 μ g/kg/min). Age-matched untreated male SHR and Wistar Kyoto rats (WKY) were used as hypertensive and normotensive controls, respectively. At the end of intervention we performed a histological study to analyze coronary artery wall width (WW), wall-to-lumen ratio (W/L), and media cross-sectional area (MCSA). Dose-response curves for acetylcholine (ACh) and sodium nitroprusside were constructed. We also assessed several plasma oxidative stress biomarkers, namely, superoxide scavenging activity (SOSA), nitrites, and total antioxidant capacity (TAC). We observed a significant reduction in WW ( P<0.001 ), W/L ( P<0.05 ), and MCSA ( P<0.01 ) and improved endothelium-dependent relaxation ( AUCSHR-E = 201.2±33 versus AUCSHR = 97.5±21 , P<0.05 ) in SHR-E compared with untreated SHR; no differences were observed for WW, MCSA, and endothelium-dependent relaxation by ACh at higher concentrations (10 −6 to 10 −4 mol/l) for SHR-E with respect to WKY. SOSA ( P<0.001 ) and nitrite ( P<0.01 ) values were significantly higher in SHR-E than in untreated SHR; however, TAC did not increase after treatment with esmolol. Esmolol improves early coronary artery remodeling in SHR.

Cite

CITATION STYLE

APA

Arnalich-Montiel, A., González, M. C., Delgado-Baeza, E., Delgado-Martos, M. J., Condezo-Hoyos, L., Martos-Rodríguez, A., … Quintana-Villamandos, B. (2014). Short-term esmolol improves coronary artery remodeling in spontaneously hypertensive rats through increased nitric oxide bioavailability and superoxide dismutase activity. BioMed Research International, 2014. https://doi.org/10.1155/2014/531087

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free