We examined the proteinase inhibitor α 2 -macroglobulin (α 2 M) in plasma from patients with multiple sclerosis (MS); a neurological disease of the central nervous system. The plasma concentrations of native and transformed α 2 M were measured in 90 patients with clinically definite MS, 73 with relapsing-remitting and 17 with secondary progressive MS, and 132 healthy individuals. Significantly lower concentrations of native α 2 M and significantly higher concentrations of transformed α 2 M were found in MS patients. A significant correlation between the concentrations of native and transformed α 2 M was found. The fraction of transformed to total α 2 M in the MS patients was 36% higher than in the healthy individuals. The results suggest an important involvement of α 2 M in regulation of increased proteolytic activity occurring in MS disease. © 2004 Elsevier B.V. All rights reserved.
Jensen, P. E. H., Humle Jørgensen, S., Datta, P., & Sørensen, P. S. (2004). Significantly increased fractions of transformed to total α 2 -macroglobulin concentrations in plasma from patients with multiple sclerosis. Biochimica et Biophysica Acta - Molecular Basis of Disease, 1690(3), 203–207. https://doi.org/10.1016/j.bbadis.2004.06.010