In Silico Studies on Development of Novel Virostatic Agents against Bluetongue Virus

  • Anupama P
N/ACitations
Citations of this article
5Readers
Mendeley users who have this article in their library.

Abstract

The core of BTV is organized into three concentric structures of which VP7 protein forms the major core protein. The subcore consists of VP3 protein and the innermost part of the core is made of three minor proteins: VP1, VP4, and VP6. Earlier it was reported that core-like particles (CLPs) composed of viral VP7 and VP3 proteins were produced in order to study role of VP7 protein in intermolecular interactions in the BTV assembly process. Site specific mutational studies revealed that substitution of the single lysine residue of VP7 (Lys-255) by leucine abrogated CLP formation, indicating a critical role for this lysine. In the present study, homology modeling, mutagenesis, and docking studies were carried out in order to design potent leads in modulation of VP7 protein in abrogating CLP formation.

Cite

CITATION STYLE

APA

Anupama, P. (2014). In Silico Studies on Development of Novel Virostatic Agents against Bluetongue Virus. ISRN Virology, 2014, 1–8. https://doi.org/10.1155/2014/450361

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free