Simple Modelling of Extracellular Matrix Alignment in Dermal Wound Healing I. Cell Flux Induced Alignment

  • Olsen L
  • Maini P
  • Sherratt J
  • et al.
N/ACitations
Citations of this article
9Readers
Mendeley users who have this article in their library.

Abstract

We present a generic model to investigate alignment due to cell movement with spefic application to collagen fibre alignment in wound healing. In particular, alignment in two orthogonal directions is considered. Numerical simulation are presented to show how alignment is affected by key parameter min the model. from a travelling wave analysis of a simplified one-dimensional version of the model we derive a first order ordinary differential equation to describe the time evolution of aligment. We conclude that in the wound healing context,faster healing wounds result in more aligment and hence more serve scarring. It is shown how the model can be extended to included orientation dependent Kinetics,multipkle cell types and several extracellular matrix materials.

Cite

CITATION STYLE

APA

Olsen, L., Maini, P. K., Sherratt, J. A., & Marchant, B. (1998). Simple Modelling of Extracellular Matrix Alignment in Dermal Wound Healing I. Cell Flux Induced Alignment. Journal of Theoretical Medicine, 1(3), 175–192. https://doi.org/10.1080/10273669808833018

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free