Single molecule conformational analysis of DNA G-quadruplexes

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Abstract

Single molecule fluorescence resonance energy transfer (FRET) can be employed to study conformational heterogeneity and real-time dynamics of biological macromolecules. Here we present single molecule studies on human genomic DNA G-quadruplex sequences that occur in the telomeres and in the promoter of a proto-oncogene. The findings are discussed with respect to the proposed biological function(s) of such motifs in living cells. © 2008 Elsevier Masson SAS. All rights reserved.

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Shirude, P. S., & Balasubramanian, S. (2008, August). Single molecule conformational analysis of DNA G-quadruplexes. Biochimie. https://doi.org/10.1016/j.biochi.2008.01.015

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