Single-cell epigenomics: Powerful new methods for understanding gene regulation and cell identity

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Abstract

© 2016 Clark et al. Emerging single-cell epigenomic methods are being developed with the exciting potential to transform our knowledge of gene regulation. Here we review available techniques and future possibilities, arguing that the full potential of single-cell epigenetic studies will be realized through parallel profiling of genomic, transcriptional, and epigenetic information.

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Clark, S. J., Lee, H. J., Smallwood, S. A., Kelsey, G., & Reik, W. (2016). Single-cell epigenomics: Powerful new methods for understanding gene regulation and cell identity. Genome Biology, 17(1). https://doi.org/10.1186/s13059-016-0944-x

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