Ageing in mammals remains an unsolved mystery. Anti-ageing is a recurring topic in the history of scientific research. Lifespan extension evoked by Sir2 protein in lower organisms has attracted a large amount of interests in the last decade. This review summarizes recent evidence supporting the role of a Sir2 mammalian homologue, SIRT1 (Silent information regulator T1), in regulating ageing and cellular senescence. The various signaling networks responsible for the anti-ageing and anti-senescence activity of SIRT1 have been discussed. In particular, a counter-balancing model involving the cross-talks between SIRT1 and AMP-activated protein kinase (AMPK), another stress and energy sensor, is suggested for controlling the senescence program in mammalian © 2010 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reservedcells.
Wang, Y., Liang, Y., & Vanhoutte, P. M. (2011, April 6). SIRT1 and AMPK in regulating mammalian senescence: A critical review and a working model. FEBS Letters. https://doi.org/10.1016/j.febslet.2010.11.047