In situ characterization of nanoparticle biomolecular interactions in complex biological media by flow cytometry

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Abstract

The protein corona on nanoparticle surfaces leads to presentation of receptor-binding motifs and defines the cellular interactions. Here, the authors use antibody mapping fluorescent quantum dot reporters, and flow cytometry to measure the availability of these recognition motifs in biological media.

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Lo Giudice, M. C., Herda, L. M., Polo, E., & Dawson, K. A. (2016). In situ characterization of nanoparticle biomolecular interactions in complex biological media by flow cytometry. Nature Communications, 7. https://doi.org/10.1038/ncomms13475

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