The fundamental unit of DNA replication, the replicon, is governed by a cis-acting replicator sequence and a trans-activating initiator factor. Despite the increased size and complexity of eukaryotic genomes, eukaryotic DNA replication continues to be guided by the fundamental principles and concepts established in the replicon model.
Creager, R. L., Li, Y., & MacAlpine, D. M. (2015, April 9). SnapShot: Origins of DNA replication. Cell. https://doi.org/10.1016/j.cell.2015.03.043