Specific titin and myomesin domains stimulate myoblast proliferation

2Citations
Citations of this article
8Readers
Mendeley users who have this article in their library.

Abstract

Myofibrillar proteins titin and myomesin stimulated myoblast proliferation as determined by MTT-test and labelled thymidine incorporation in the DNA. Specific Fn type III and Ig-like domains of these proteins were able to exert mitogenic effects as well. Proliferative effect of Fn type III domains was highly sensitive to inhibition of Ca2+/calmodulin dependent protein kinase, whereas the effect of Ig-like domains showed greater sensitivity to the inhibition of adenylyl cyclase – cAMP – PKA pathway. IGF-1 autocrine signalling inhibition partially suppressed mitogenic effects revealed by both domain types.

Cite

CITATION STYLE

APA

Kravchenko, I. V., Furalyov, V. A., & Popov, V. O. (2017). Specific titin and myomesin domains stimulate myoblast proliferation. Biochemistry and Biophysics Reports, 9, 226–231. https://doi.org/10.1016/j.bbrep.2016.12.007

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free