Spirochetes are a major threat to public health. However, the exact pathogenesis of spi-rochetal diseases remains unclear. Spirochetes express lipoproteins that often determine the cross talk between the host and spirochetes. Lipoproteins are pro-inflammatory, modulatory of immune responses, and enable the spirochetes to evade the immune system. In this article, we review the modulatory effects of spirochetal lipoproteins related to immune evasion. Understanding lipoprotein-induced immunomodulation will aid in elucidating innate pathogenesis processes and subsequent adaptive mechanisms potentially relevant to spirochetal disease vaccine development and treatment.
Christodoulides, A., Boyadjian, A., & Kelesidis, T. (2017, March 29). Spirochetal lipoproteins and immune evasion. Frontiers in Immunology. Frontiers Research Foundation. https://doi.org/10.3389/fimmu.2017.00364