Spirocyclic Scaffolds in Drug Discovery

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Abstract

Although spirocycles have been incorporated into drugs and explored in drug discovery for over five decades, recent years have seen a greater variety and number of spirocycles employed in drug discovery. This increase has been driven by improved synthetic methods, the quest for novel intellectual property, and the desirable, intrinsically three-dimensional nature of spirocycles. In this article, we discuss the conformational analysis of spirocycles, spirocyclic drugs, and selected examples of spirocyclic compounds from the medicinal chemistry literature.

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Tice, C. M., Zheng, Y., & Singh, S. B. (2017). Spirocyclic Scaffolds in Drug Discovery. In Comprehensive Medicinal Chemistry III (Vol. 1–8, pp. 211–263). Elsevier Inc. https://doi.org/10.1016/B978-0-12-409547-2.12291-7

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