The effector proteins IpaJ and VirA, from the bacterium Shigella flexneri, block the general secretory pathway (GSP) at different stages. In this issue of Cell Host & Microbe, Dobbs et al. (2015) use these proteins as a tool to pinpoint STING trafficking and signaling to the ER-Golgi intermediate compartment (ERGIC).
Hiller, B., & Hornung, V. (2015, August 12). STING signaling the enERGIC way. Cell Host and Microbe. Cell Press. https://doi.org/10.1016/j.chom.2015.07.014