Ras interacts with many downstream effectors that regulate complex cytoplasmic signaling networks. In this issue, Gupta et al. (2007) use mouse models of Ras-mediated tumorigenesis to show that the interaction of Ras with a single isoform of phosphatidylinositol 3-kinase (PI3K), called p110α (PIK3CA), is critical for tumor formation. This result will stimulate re-evaluation of pharmacological approaches to target Ras for cancer treatment. © 2007 Elsevier Inc. All rights reserved.
Der, C. J., & Van Dyke, T. (2007, June 1). Stopping Ras in Its Tracks. Cell. https://doi.org/10.1016/j.cell.2007.05.031