Objectives: HIV-infected patients present excess cardiovascular (CV) mortality compared to the general population. In addition to CV risk factors, vitamin D insufficiency, a common condition in HIV-infected patients, is increasingly associated with CV risk. Specific study of central arterial stiffness and its determinants may improve risk prediction in this population. Methods: In order to determine potential predictor role of HIV-related factors, antiretroviral therapy and vitamin D on structural and functional arterial parameters, we conducted a cross-sectional study with inclusion of 178 HIV-infected patients. In addition to carotid intima-media thickness (IMT), arterial stiffness and wave reflection analysis were performed with aortic pulse wave velocity (PWV), carotid augmentation index (AIx) and pulse pressure amplification (PPA) measurements. Results: Aortic PWV was insignificantly higher than the theoretical value according to age and blood pressure, and independent of HIV-related parameters. Carotid AIx was positively and independently correlated with CD4 T-cell count. A positive correlation between vitamin D and PPA persisted in multiple regression analysis independently of other confounders. No HIV-related parameters or vitamin D entered the multiple regression analysis of carotid IMT and carotid plaque. Conclusions: In our study population, HIV infection was associated with marginally increased aortic stiffness. Better immune status was associated with enhanced wave reflection suggesting that immunodeficiency may not account primarily for increased CV risk in HIV-infected patients. A positive correlation between vitamin D and a combined index of arterial stiffness and wave reflection suggests beneficial impact of vitamin D on CV diseases via modifications of central arterial parameters.
Yannoutsos, A. (2014). Structural and Functional Arterial Parameters, Immunovirological Control and Vitamin D in HIV-Infected Patients. Journal of AIDS & Clinical Research, 05(11). https://doi.org/10.4172/2155-6113.1000375