Structural and functional implications of positive selection at the primate angiogenin gene

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Abstract

Angiogenesis, the formation of new blood vessels, is a primordial process in development and its dysregulation has a central role in the pathogenesis of many diseases. Angiogenin (ANG), a peculiar member of the RNase A superfamily, is a potent inducer of angiogenesis involved in many different types of cancer, amyotrophic lateral sclerosis and also with a possible role in the innate immune defense. The evolutionary path of this family has been a highly dynamic one, where positive selection has played a strong role. In this work we used a combined gene and protein level approach to determine the main sites under diversifying selection on the primate ANG gene and analyze its structural and functional implications.

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Osorio, D. S., Antunes, A., & Ramos, M. J. (2007). Structural and functional implications of positive selection at the primate angiogenin gene. BMC Evolutionary Biology, 7. https://doi.org/10.1186/1471-2148-7-167

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