Structure of the human metapneumovirus fusion protein with neutralizing antibody identifies a pneumovirus antigenic site

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Abstract

Human metapneumovirus and respiratory syncytial virus cause lower respiratory tract infections. The virus fusion (F) glycoprotein promotes membrane fusion by refolding from a metastable pre-fusion to a stable post-fusion conformation. F is also a major target of the neutralizing antibody response. Here we show that a potently neutralizing anti-human metapneumovirus antibody (DS7) binds a structurally invariant domain of F, revealing a new epitope that could be targeted in vaccine development.

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Wen, X., Krause, J. C., Leser, G. P., Cox, R. G., Lamb, R. A., Williams, J. V., … Jardetzky, T. S. (2012). Structure of the human metapneumovirus fusion protein with neutralizing antibody identifies a pneumovirus antigenic site. Nature Structural and Molecular Biology, 19(4), 461–463. https://doi.org/10.1038/nsmb.2250

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