Studies on the interaction between TWEAK and the death receptor WSL-1/TRAMP (DR3)

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Abstract

WSL-1/TRAMP (DR3) is a member of the tumour necrosis factor (TNF) receptor superfamily which exhibits effects on NF-κB activation and apoptosis. TWEAK, a novel TNF-related molecule, has been proposed as the ligand for this receptor. Utilising both human and murine TWEAK ligand, it is shown that TWEAK and WSL-1/TRAMP do not interact in an in vitro binding assay and that TWEAK binds strongly to cells that do not express WSL-1/TRAMP on the cell surface. Biological activity of TWEAK is also observed in these cells. Finally, cells isolated from WSL-1/TRAMP knockout mice are shown to retain their ability to interact with TWEAK. These results suggest that WSL-1/TRAMP is not the major receptor for TWEAK.

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Kaptein, A., Jansen, M., Dilaver, G., Kitson, J., Dash, L., Wang, E., … Farrow, S. N. (2000). Studies on the interaction between TWEAK and the death receptor WSL-1/TRAMP (DR3). FEBS Letters, 485(2–3), 135–141. https://doi.org/10.1016/S0014-5793(00)02219-5

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