A study on the human mitochondrial RNA polymerase activity points to existence of a transcription factor B-like protein

13Citations
Citations of this article
9Readers
Mendeley users who have this article in their library.

Abstract

In the present work, the RNA polymerase activity of the human mitochondrial RNA polymerase mature protein (h-mtRPOLm) is shown, and its molecular activity calculated (2.1 ± 0.9 min-1). An activity analysis of h-mtRPOLm and deleted versions of it has demonstrated that the entire recombinant protein is required for this activity. In addition, h-mtRPOLm alone or in presence of the known mitochondrial transcription factors (human mitochondrial transcription factor A and/or human mitochondrial transcription termination factor) is not able to initiate transcription from the specific human mitochondrial promoters pointing to the existence of a human mitochondrial transcription factor B-like protein. © 2001 Federation of European Biochemical Societies. Published by Elsevier Science B.V. All rights reserved.

Cite

CITATION STYLE

APA

Prieto-Martín, A., Montoya, J., & Martínez-Azorín, F. (2001). A study on the human mitochondrial RNA polymerase activity points to existence of a transcription factor B-like protein. FEBS Letters, 503(1), 51–55. https://doi.org/10.1016/S0014-5793(01)02695-3

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free